MicroRNAs (miRNAs) are small non-coding RNAs that repress the translation and reduce the stability of target mRNAs in animal cells. Post-transcriptional regulation mediated by miRNAs is a highly conserved mechanism utilized by organisms throughout phylogeny to fine tune gene expression.

MicroRNA (miRNA) is een vorm van niet-coderend RNA van 20 tot 25 nucleotiden lang en is onderdeel van de epigenetische mechanismen die de expressie van genen reguleren. De term miRNA werd in oktober 2001 voor het eerst geïntroduceerd in een drietal artikelen in het wetenschappelijke tijdschrift Science.

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by binding to the cellular transcript leading to translational repression or  7 Jan 2014 Abstract: Micro ribonucleic acids (miRNAs) are small non-coding RNA segments that have a role in the regulation of normal cellular development  17 Jul 2019 The scientists also discovered that microRNA concentrations in cell nuclei The findings strongly suggest that microRNAs play a role in the  Dysregulated miRNAs have been found in >50% of all forms of cancer and play hence a central role in cancer development. Understanding miRNA function and  MicroRNA biogenesis and Argonaute function in Dictyostelium discoideum In this thesis, I aimed to understand miRNA maturation in the social amoeba  I växter uppkommer mirnas från primära transkriptioner som kallas Bartel, D. P. MicroRNAs: target recognition and regulatory functions. Cell. av H Xie Jr · 2013 — In Paper I, we describe the functional roles and targets of miR-205 in human cervical cancer cells. Using miR-205 over-expression and suppression experiments,  Titel, Non-coding RNAs, microRNAs and their role in human diseases explain the term microRNA, differences and similarities between them and ordinary  Inhibition of microRNA function by antimiR oligonucleotides.

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The miRNA plays an important regulation role in gene expression, and also Study on the microRNA Expression Level in Postmenopausal Osteoporosis. MicroRnA: Key regulators of gene expression homology between the miRnA and the target mRnA The discovery of miRnA function and regulation was. av H Jiang · 2017 · Citerat av 31 — MicroRNA function transitions from regulating developmental genes to transposable elements during the maturation of pollen bioRxiv  Följ oss: - Twitter · - Facebook · - RSS · Vetenskap & hälsa. Populärvetenskapligt om forskning inom medicin och hälsa.

MicroRNAs (miRNAs) are endogenous approximately 22 nt RNAs that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regu … microRNAs (miRNAs) are small noncoding RNAs that play important roles in posttranscriptional gene regulation. In animal cells, miRNAs regulate their targets by translational inhibition and mRNA destabilization.

MicroRNA: function, detection, and bioanalysis

In miRTarBase, 295, 425, 40, 96, and Noguchi S, Kumazaki M, Mori T, Baba K, Okuda M, Mizuno T, et al. Analysis of MicroRNA-203 Function in CREB/MITF/RAB27a Pathway: Comparison Between Canine and Human Melanoma Cells. Vet Comp Oncol (2016) 14(4):384–94.

These technologies have convincingly demonstrated their efficacy and reliability in producing gain-of-function or loss-of-function of miRNAs through targeting 

140 - 153 Article Download PDF View Record in Scopus Google Scholar 2020-06-16 · In this Review, Brennan and Henshall discuss how microRNAs determine and control neuronal and glial functions, how this process is altered in states associated with hyperexcitability, and the MicroRNA-Initiated and Intracellular Na+-Fueled DNAzyme Motor for Differentiating Molecular Subtypes of Nonsmall Cell Lung Cancer. Analytical Chemistry 2020, 92 (11) , 7404-7408. Strategies to Modulate MicroRNA Functions for the Treatment of Cancer or Organ Injury Tae Jin Lee , Xiaoyi Yuan , Keith Kerr , Ji Young Yoo , Dong H. Kim , Balveen Kaur and Holger K. Eltzschig Eric L. Barker, ASSOCIATE EDITOR 2013-04-01 · The microRNA bantam functions in epithelial cells to regulate scaling growth of dendrite arbors in Drosophila sensory neurons Neuron , 63 ( 2009 ) , pp.

av M Moreau · 2013 · Citerat av 40 — a miRNA expression atlas of the developing human brain, and we propose a classification scheme to guide future studies of neurobiological function. Microrna: Biology, Function and Express: Clarke, Neil J., Sanseau, Philippe: Amazon.se: Books. By allowing third party services, you accept their cookies and the use of tracking technologies necessary for their proper functioning. Read about  In pancreatic β cells, miRNAs have been largely unstudied and little is known about how specific miRNAs MicroRNA-7a regulates pancreatic β cell function. This book discusses topics related to the topological structure and biological function of gene networks regulated by microRNAs. It focuses on analyzing the  Pris: 1989 kr.
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Trehalose 6-phosphate (T6P) is a sugar molecule with signaling function reporting the  The regulatory role of microRNA in human adipocytes and their link to insulin resistance. Detta är en avhandling från Stockholm : Karolinska Institutet, Dept of  Gain-of-function mutation of microRNA-140 in human skeletal dysplasia https://www.nature.com/articles/s41591-019-0353-2.

Se hela listan på academic.oup.com The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans. Dev. Cell.
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during infectious bronchitis virus infection, but their role in regulating host immune function has not been explored. Here, microarrays of mRNAs, miRNAs, and 

RNA: A publication of  the microRNA miR156, in response to sucrose status. Trehalose 6-phosphate (T6P) is a sugar molecule with signaling function reporting the  The regulatory role of microRNA in human adipocytes and their link to insulin resistance.